Nineteen of the Russian's 21 titles have been won on hard surfaces
A resurgent Medvedev claimed his initial championship for 882 days with victory over opponent Moutet in the tournament championship match.
The Russian, a former number one, has experienced a challenging season, winning just one match at the major tournaments and suffering a difficult moment at the US Open.
The player's inconsistency on the tennis tour - and issues with his serve in specific - led to him dropping out of the elite rankings and finally separating with former trainer Gilles Cervara.
Currently collaborating with his coach and Goetzke, Medvedev has gradually advanced in the recent weeks - peaking in a tightly fought 7-5 4-6 6-3 victory over challenger Corentin Moutet.
This marks the player's first championship after the Rome competition and initial on a hard surface since that period of the previous year.
The win also signifies he has won twenty-one championships at twenty-one distinct events.
"It's the first time I have attended a competition with my both daughters at once, so to secure a championship is especially meaningful," said ranked player Medvedev.
"This title is in tribute of my second daughter my daughter, because the initial championship I got when my child Alisa was born was for her."
The tennis star, the 2021 US Open champion, had failed in his past six championship matches, including in Halle in the past months.
Medvedev's defensive strategy and regular reactions on the tennis court had prompted observers to wonder if his capacity to perform at the top level was concluded.
However the athlete has altered his approach in the last few weeks, attempting to come to the net and play assertively, reinforced by an enhanced serve.
He fought back from a deficit in the first set against the challenging opponent, securing four of the final five games to take the lead.
The competitors traded breaks in the following set before the challenger, striving for his maiden professional victory, gained dominance to force a third set.
Moutet rescued 4 early-game break points in a tight final set before the champion broke to fifteen to close out the victory.
Fittingly, Medvedev clinched victory with a shot at the net area, with the Frenchman incapable to handle a return after two hours and 38 minutes.